*
|
The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.
|
CUSIP No. 032420101
|
Page 2 of 16
|
1
|
NAMES OF REPORTING PERSONS
Venrock Associates IV, L.P.
|
||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) ¨ (b) þ (1)
|
||
3
|
SEC USE ONLY
|
||
4
|
SOURCE OF FUNDS (SEE INSTRUCTIONS)
WC
|
||
5
|
CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)
¨
|
||
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE VOTING POWER
0
|
|
8
|
SHARED VOTING POWER
783,022 shares of Common Stock (2)
|
||
9
|
SOLE DISPOSITIVE POWER
0
|
||
10
|
SHARED DISPOSITIVE POWER
783,022 shares of Common Stock (2)
|
||
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
783,022 shares of Common Stock (2)
|
||
12
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
þ (3)
|
||
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
1.8%(4)
|
||
14
|
TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
PN
|
(1)
|
This Schedule 13D/A is being filed by Venrock Associates IV, L.P. (“VAIV”), Venrock Partners, L.P. (“VP”), Venrock Entrepreneurs Fund IV, L.P. (“VEFIV”), VR Management, LLC (“VRM”), Venrock Management IV, LLC (“VMIV”), Venrock Partners Management, LLC (“VPM”), and VEF Management IV, LLC (“VEFMIV” and, together with VAIV, VP, VEFIV, VRM, VMIV, and VPM, the “Venrock IV Entities”), Venrock Healthcare Capital Partners, L.P. (“VHCP”), VHCP Co-Investment Holdings, LLC (“VHCP Co.”), VHCP Management, LLC (“VHCPM” and, together with VHCP and VHCP Co., the “Venrock Healthcare Entities” and the Venrock Healthcare Entities together with Venrock IV Entities, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D/A.
|
(2)
|
Includes (i) 566,247 shares held by VAIV, (ii) 115,475 shares held by VP, (iii) 13,913 shares held by VEFIV, and (iv) 87,387 shares issuable upon the exercise of options held by Anders Hove (“Hove”) within 60 days of the date of this filing. Under an agreement between Hove and VRM, Hove is deemed to hold the shares at the direction, and for the sole benefit, of VRM.
|
(3)
|
The shares included on rows 8, 10 and 11 do not include an aggregate of 529,900 shares held by VHCP and VHCP Co. The Venrock IV Entities disclaim beneficial ownership over the shares held by the Venrock Healthcare Entities.
|
(4)
|
This percentage is based upon (i) 44,023,338 shares of the Issuer’s common stock outstanding as of August 3, 2015, as reported in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on August 7, 2015, plus (ii) 87,387 shares of Common Stock issuable upon the exercise of options beneficially owned by the Reporting Person within 60 days of the date of this filing.
|
CUSIP No. 032420101
|
Page 3 of 16
|
1
|
NAMES OF REPORTING PERSONS
Venrock Partners, L.P.
|
||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) ¨ (b) þ (1)
|
||
3
|
SEC USE ONLY
|
||
4
|
SOURCE OF FUNDS (SEE INSTRUCTIONS)
WC
|
||
5
|
CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)
¨
|
||
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE VOTING POWER
0
|
|
8
|
SHARED VOTING POWER
783,022 shares of Common Stock (2)
|
||
9
|
SOLE DISPOSITIVE POWER
0
|
||
10
|
SHARED DISPOSITIVE POWER
783,022 shares of Common Stock (2)
|
||
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
783,022 shares of Common Stock (2)
|
||
12
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
þ (3)
|
||
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
1.8%(4)
|
||
14
|
TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
PN
|
(1)
|
This Schedule 13D/A is being filed by Venrock Associates IV, L.P. (“VAIV”), Venrock Partners, L.P. (“VP”), Venrock Entrepreneurs Fund IV, L.P. (“VEFIV”), VR Management, LLC (“VRM”), Venrock Management IV, LLC (“VMIV”), Venrock Partners Management, LLC (“VPM”), and VEF Management IV, LLC (“VEFMIV” and, together with VAIV, VP, VEFIV, VRM, VMIV, and VPM, the “Venrock IV Entities”), Venrock Healthcare Capital Partners, L.P. (“VHCP”), VHCP Co-Investment Holdings, LLC (“VHCP Co.”), VHCP Management, LLC (“VHCPM” and, together with VHCP and VHCP Co., the “Venrock Healthcare Entities” and the Venrock Healthcare Entities together with Venrock IV Entities, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D/A.
|
(2)
|
Includes (i) 566,247 shares held by VAIV, (ii) 115,475 shares held by VP, (iii) 13,913 shares held by VEFIV, and (iv) 87,387 shares issuable upon the exercise of options held by Anders Hove (“Hove”) within 60 days of the date of this filing. Under an agreement between Hove and VRM, Hove is deemed to hold the shares at the direction, and for the sole benefit, of VRM.
|
(3)
|
The shares included on rows 8, 10 and 11 do not include an aggregate of 529,900 shares held by VHCP and VHCP Co. The Venrock IV Entities disclaim beneficial ownership over the shares held by the Venrock Healthcare Entities.
|
(4)
|
This percentage is based upon (i) 44,023,338 shares of the Issuer’s common stock outstanding as of August 3, 2015, as reported in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on August 7, 2015, plus (ii) 87,387 shares of Common Stock issuable upon the exercise of options beneficially owned by the Reporting Person within 60 days of the date of this filing.
|
CUSIP No. 032420101
|
Page 4 of 16
|
1
|
NAMES OF REPORTING PERSONS
Venrock Entrepreneurs Fund IV, L.P.
|
||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) ¨ (b) þ (1)
|
||
3
|
SEC USE ONLY
|
||
4
|
SOURCE OF FUNDS (SEE INSTRUCTIONS)
WC
|
||
5
|
CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)
¨
|
||
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE VOTING POWER
0
|
|
8
|
SHARED VOTING POWER
783,022 shares of Common Stock (2)
|
||
9
|
SOLE DISPOSITIVE POWER
0
|
||
10
|
SHARED DISPOSITIVE POWER
783,022 shares of Common Stock (2)
|
||
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
783,022 shares of Common Stock (2)
|
||
12
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
þ (3)
|
||
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
1.8%(4)
|
||
14
|
TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
PN
|
(1)
|
This Schedule 13D/A is being filed by Venrock Associates IV, L.P. (“VAIV”), Venrock Partners, L.P. (“VP”), Venrock Entrepreneurs Fund IV, L.P. (“VEFIV”), VR Management, LLC (“VRM”), Venrock Management IV, LLC (“VMIV”), Venrock Partners Management, LLC (“VPM”), and VEF Management IV, LLC (“VEFMIV” and, together with VAIV, VP, VEFIV, VRM, VMIV, and VPM, the “Venrock IV Entities”), Venrock Healthcare Capital Partners, L.P. (“VHCP”), VHCP Co-Investment Holdings, LLC (“VHCP Co.”), VHCP Management, LLC (“VHCPM” and, together with VHCP and VHCP Co., the “Venrock Healthcare Entities” and the Venrock Healthcare Entities together with Venrock IV Entities, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D/A.
|
(2)
|
Includes (i) 566,247 shares held by VAIV, (ii) 115,475 shares held by VP, (iii) 13,913 shares held by VEFIV, and (iv) 87,387 shares issuable upon the exercise of options held by Anders Hove (“Hove”) within 60 days of the date of this filing. Under an agreement between Hove and VRM, Hove is deemed to hold the shares at the direction, and for the sole benefit, of VRM.
|
(3)
|
The shares included on rows 8, 10 and 11 do not include an aggregate of 529,900 shares held by VHCP and VHCP Co. The Venrock IV Entities disclaim beneficial ownership over the shares held by the Venrock Healthcare Entities.
|
(4)
|
This percentage is based upon (i) 44,023,338 shares of the Issuer’s common stock outstanding as of August 3, 2015, as reported in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on August 7, 2015, plus (ii) 87,387 shares of Common Stock issuable upon the exercise of options beneficially owned by the Reporting Person within 60 days of the date of this filing.
|
CUSIP No. 032420101
|
Page 5 of 16
|
1
|
NAMES OF REPORTING PERSONS
VR Management, LLC
|
||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) ¨ (b) þ (1)
|
||
3
|
SEC USE ONLY
|
||
4
|
SOURCE OF FUNDS (SEE INSTRUCTIONS)
WC
|
||
5
|
CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)
¨
|
||
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE VOTING POWER
0
|
|
8
|
SHARED VOTING POWER
783,022 shares of Common Stock (2)
|
||
9
|
SOLE DISPOSITIVE POWER
0
|
||
10
|
SHARED DISPOSITIVE POWER
783,022 shares of Common Stock (2)
|
||
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
783,022 shares of Common Stock (2)
|
||
12
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
þ (3)
|
||
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
1.8%(4)
|
||
14
|
TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
OO
|
(1)
|
This Schedule 13D/A is being filed by Venrock Associates IV, L.P. (“VAIV”), Venrock Partners, L.P. (“VP”), Venrock Entrepreneurs Fund IV, L.P. (“VEFIV”), VR Management, LLC (“VRM”), Venrock Management IV, LLC (“VMIV”), Venrock Partners Management, LLC (“VPM”), and VEF Management IV, LLC (“VEFMIV” and, together with VAIV, VP, VEFIV, VRM, VMIV, and VPM, the “Venrock IV Entities”), Venrock Healthcare Capital Partners, L.P. (“VHCP”), VHCP Co-Investment Holdings, LLC (“VHCP Co.”), VHCP Management, LLC (“VHCPM” and, together with VHCP and VHCP Co., the “Venrock Healthcare Entities” and the Venrock Healthcare Entities together with Venrock IV Entities, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D/A.
|
(2)
|
Includes (i) 566,247 shares held by VAIV, (ii) 115,475 shares held by VP, (iii) 13,913 shares held by VEFIV, and (iv) 87,387 shares issuable upon the exercise of options held by Anders Hove (“Hove”) within 60 days of the date of this filing. Under an agreement between Hove and VRM, Hove is deemed to hold the shares at the direction, and for the sole benefit, of VRM.
|
(3)
|
The shares included on rows 8, 10 and 11 do not include an aggregate of 529,900 shares held by VHCP and VHCP Co. The Venrock IV Entities disclaim beneficial ownership over the shares held by the Venrock Healthcare Entities.
|
(4)
|
This percentage is based upon (i) 44,023,338 shares of the Issuer’s common stock outstanding as of August 3, 2015, as reported in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on August 7, 2015, plus (ii) 87,387 shares of Common Stock issuable upon the exercise of options beneficially owned by the Reporting Person within 60 days of the date of this filing.
|
CUSIP No. 032420101
|
Page 6 of 16
|
1
|
NAMES OF REPORTING PERSONS
Venrock Management IV, LLC
|
||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) ¨ (b) þ (1)
|
||
3
|
SEC USE ONLY
|
||
4
|
SOURCE OF FUNDS (SEE INSTRUCTIONS)
WC
|
||
5
|
CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)
¨
|
||
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE VOTING POWER
0
|
|
8
|
SHARED VOTING POWER
783,022 shares of Common Stock (2)
|
||
9
|
SOLE DISPOSITIVE POWER
0
|
||
10
|
SHARED DISPOSITIVE POWER
783,022 shares of Common Stock (2)
|
||
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
783,022 shares of Common Stock (2)
|
||
12
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
þ (3)
|
||
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
1.8%(4)
|
||
14
|
TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
OO
|
(1)
|
This Schedule 13D/A is being filed by Venrock Associates IV, L.P. (“VAIV”), Venrock Partners, L.P. (“VP”), Venrock Entrepreneurs Fund IV, L.P. (“VEFIV”), VR Management, LLC (“VRM”), Venrock Management IV, LLC (“VMIV”), Venrock Partners Management, LLC (“VPM”), and VEF Management IV, LLC (“VEFMIV” and, together with VAIV, VP, VEFIV, VRM, VMIV, and VPM, the “Venrock IV Entities”), Venrock Healthcare Capital Partners, L.P. (“VHCP”), VHCP Co-Investment Holdings, LLC (“VHCP Co.”), VHCP Management, LLC (“VHCPM” and, together with VHCP and VHCP Co., the “Venrock Healthcare Entities” and the Venrock Healthcare Entities together with Venrock IV Entities, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D/A.
|
(2)
|
Includes (i) 566,247 shares held by VAIV, (ii) 115,475 shares held by VP, (iii) 13,913 shares held by VEFIV, and (iv) 87,387 shares issuable upon the exercise of options held by Anders Hove (“Hove”) within 60 days of the date of this filing. Under an agreement between Hove and VRM, Hove is deemed to hold the shares at the direction, and for the sole benefit, of VRM.
|
(3)
|
The shares included on rows 8, 10 and 11 do not include an aggregate of 529,900 shares held by VHCP and VHCP Co. The Venrock IV Entities disclaim beneficial ownership over the shares held by the Venrock Healthcare Entities.
|
(4)
|
This percentage is based upon (i) 44,023,338 shares of the Issuer’s common stock outstanding as of August 3, 2015, as reported in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on August 7, 2015, plus (ii) 87,387 shares of Common Stock issuable upon the exercise of options beneficially owned by the Reporting Person within 60 days of the date of this filing.
|
CUSIP No. 032420101
|
Page 7 of 16
|
1
|
NAMES OF REPORTING PERSONS
Venrock Partners Management, LLC
|
||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) ¨ (b) þ (1)
|
||
3
|
SEC USE ONLY
|
||
4
|
SOURCE OF FUNDS (SEE INSTRUCTIONS)
WC
|
||
5
|
CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)
¨
|
||
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE VOTING POWER
0
|
|
8
|
SHARED VOTING POWER
783,022 shares of Common Stock (2)
|
||
9
|
SOLE DISPOSITIVE POWER
0
|
||
10
|
SHARED DISPOSITIVE POWER
783,022 shares of Common Stock (2)
|
||
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
783,022 shares of Common Stock (2)
|
||
12
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
þ (3)
|
||
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
1.8%(4)
|
||
14
|
TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
OO
|
(1)
|
This Schedule 13D/A is being filed by Venrock Associates IV, L.P. (“VAIV”), Venrock Partners, L.P. (“VP”), Venrock Entrepreneurs Fund IV, L.P. (“VEFIV”), VR Management, LLC (“VRM”), Venrock Management IV, LLC (“VMIV”), Venrock Partners Management, LLC (“VPM”), and VEF Management IV, LLC (“VEFMIV” and, together with VAIV, VP, VEFIV, VRM, VMIV, and VPM, the “Venrock IV Entities”), Venrock Healthcare Capital Partners, L.P. (“VHCP”), VHCP Co-Investment Holdings, LLC (“VHCP Co.”), VHCP Management, LLC (“VHCPM” and, together with VHCP and VHCP Co., the “Venrock Healthcare Entities” and the Venrock Healthcare Entities together with Venrock IV Entities, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D/A.
|
(2)
|
Includes (i) 566,247 shares held by VAIV, (ii) 115,475 shares held by VP, (iii) 13,913 shares held by VEFIV, and (iv) 87,387 shares issuable upon the exercise of options held by Anders Hove (“Hove”) within 60 days of the date of this filing. Under an agreement between Hove and VRM, Hove is deemed to hold the shares at the direction, and for the sole benefit, of VRM.
|
(3)
|
The shares included on rows 8, 10 and 11 do not include an aggregate of 529,900 shares held by VHCP and VHCP Co. The Venrock IV Entities disclaim beneficial ownership over the shares held by the Venrock Healthcare Entities.
|
(4)
|
This percentage is based upon (i) 44,023,338 shares of the Issuer’s common stock outstanding as of August 3, 2015, as reported in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on August 7, 2015, plus (ii) 87,387 shares of Common Stock issuable upon the exercise of options beneficially owned by the Reporting Person within 60 days of the date of this filing.
|
CUSIP No. 032420101
|
Page 8 of 16
|
1
|
NAMES OF REPORTING PERSONS
VEF Management IV, LLC
|
||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) ¨ (b) þ (1)
|
||
3
|
SEC USE ONLY
|
||
4
|
SOURCE OF FUNDS (SEE INSTRUCTIONS)
WC
|
||
5
|
CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)
¨
|
||
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE VOTING POWER
0
|
|
8
|
SHARED VOTING POWER
783,022 shares of Common Stock (2)
|
||
9
|
SOLE DISPOSITIVE POWER
0
|
||
10
|
SHARED DISPOSITIVE POWER
783,022 shares of Common Stock (2)
|
||
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
783,022 shares of Common Stock (2)
|
||
12
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
þ (3)
|
||
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
1.8%(4)
|
||
14
|
TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
OO
|
(1)
|
This Schedule 13D/A is being filed by Venrock Associates IV, L.P. (“VAIV”), Venrock Partners, L.P. (“VP”), Venrock Entrepreneurs Fund IV, L.P. (“VEFIV”), VR Management, LLC (“VRM”), Venrock Management IV, LLC (“VMIV”), Venrock Partners Management, LLC (“VPM”), and VEF Management IV, LLC (“VEFMIV” and, together with VAIV, VP, VEFIV, VRM, VMIV, and VPM, the “Venrock IV Entities”), Venrock Healthcare Capital Partners, L.P. (“VHCP”), VHCP Co-Investment Holdings, LLC (“VHCP Co.”), VHCP Management, LLC (“VHCPM” and, together with VHCP and VHCP Co., the “Venrock Healthcare Entities” and the Venrock Healthcare Entities together with Venrock IV Entities, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D/A.
|
(2)
|
Includes (i) 566,247 shares held by VAIV, (ii) 115,475 shares held by VP, (iii) 13,913 shares held by VEFIV, and (iv) 87,387 shares issuable upon the exercise of options held by Anders Hove (“Hove”) within 60 days of the date of this filing. Under an agreement between Hove and VRM, Hove is deemed to hold the shares at the direction, and for the sole benefit, of VRM.
|
(3)
|
The shares included on rows 8, 10 and 11 do not include an aggregate of 529,900 shares held by VHCP and VHCP Co. The Venrock IV Entities disclaim beneficial ownership over the shares held by the Venrock Healthcare Entities.
|
(4)
|
This percentage is based upon (i) 44,023,338 shares of the Issuer’s common stock outstanding as of August 3, 2015, as reported in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on August 7, 2015, plus (ii) 87,387 shares of Common Stock issuable upon the exercise of options beneficially owned by the Reporting Person within 60 days of the date of this filing.
|
CUSIP No. 032420101
|
Page 9 of 16
|
1
|
NAMES OF REPORTING PERSONS
Venrock Healthcare Capital Partners, L.P.
|
||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) ¨ (b) þ (1)
|
||
3
|
SEC USE ONLY
|
||
4
|
SOURCE OF FUNDS (SEE INSTRUCTIONS)
WC
|
||
5
|
CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)
¨
|
||
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE VOTING POWER
0
|
|
8
|
SHARED VOTING POWER
529,900 shares of Common Stock (2)
|
||
9
|
SOLE DISPOSITIVE POWER
0
|
||
10
|
SHARED DISPOSITIVE POWER
529,900 shares of Common Stock (2)
|
||
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
529,900 shares of Common Stock (2)
|
||
12
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
þ (3)
|
||
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
1.2%(4)
|
||
14
|
TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
PN
|
(1)
|
This Schedule 13D/A is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D/A.
|
(2)
|
Includes (i) 447,957 shares held by VHCP and (ii) 81,943 shares held by VHCP Co. VHCPM is the sole general partner of VHCP and the sole manager of VHCP Co.
|
(3)
|
The shares included on rows 8, 10 and 11 do not include an aggregate of 783,022 shares held by VAIV, VP and VEFIV, 87,387 shares of which are issuable upon the exercise of options held by Hove for the sole benefit of VRM, which options are exercisable within 60 days of the date of this filing. The Venrock Healthcare Entities disclaim beneficial ownership over the shares held by the Venrock IV Entities.
|
(4)
|
This percentage is based upon 44,023,338 shares of the Issuer’s common stock outstanding as of August 3, 2015, as reported in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on August 7, 2015.
|
CUSIP No. 032420101
|
Page 10 of 16
|
1
|
NAMES OF REPORTING PERSONS
VHCP Co-Investment Holdings, LLC
|
||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) ¨ (b) þ (1)
|
||
3
|
SEC USE ONLY
|
||
4
|
SOURCE OF FUNDS (SEE INSTRUCTIONS)
WC
|
||
5
|
CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)
¨
|
||
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE VOTING POWER
0
|
|
8
|
SHARED VOTING POWER
529,900 shares of Common Stock (2)
|
||
9
|
SOLE DISPOSITIVE POWER
0
|
||
10
|
SHARED DISPOSITIVE POWER
529,900 shares of Common Stock (2)
|
||
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
529,900 shares of Common Stock (2)
|
||
12
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
þ (3)
|
||
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
1.2%(4)
|
||
14
|
TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
OO
|
(1)
|
This Schedule 13D/A is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D/A.
|
(2)
|
Includes (i) 447,957 shares held by VHCP and (ii) 81,943 shares held by VHCP Co. VHCPM is the sole general partner of VHCP and the sole manager of VHCP Co.
|
(3)
|
The shares included on rows 8, 10 and 11 do not include an aggregate of 783,022 shares held by VAIV, VP and VEFIV, 87,387 shares of which are issuable upon the exercise of options held by Hove for the sole benefit of VRM, which options are exercisable within 60 days of the date of this filing. The Venrock Healthcare Entities disclaim beneficial ownership over the shares held by the Venrock IV Entities.
|
(4)
|
This percentage is based upon 44,023,338 shares of the Issuer’s common stock outstanding as of August 3, 2015, as reported in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on August 7, 2015.
|
CUSIP No. 032420101
|
Page 11 of 16
|
1
|
NAMES OF REPORTING PERSONS
VHCP Management, LLC
|
||
2
|
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) ¨ (b) þ (1)
|
||
3
|
SEC USE ONLY
|
||
4
|
SOURCE OF FUNDS (SEE INSTRUCTIONS)
WC
|
||
5
|
CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e)
¨
|
||
6
|
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH
|
7
|
SOLE VOTING POWER
0
|
|
8
|
SHARED VOTING POWER
529,900 shares of Common Stock (2)
|
||
9
|
SOLE DISPOSITIVE POWER
0
|
||
10
|
SHARED DISPOSITIVE POWER
529,900 shares of Common Stock (2)
|
||
11
|
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
529,900 shares of Common Stock (2)
|
||
12
|
CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
þ (3)
|
||
13
|
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
1.2%(4)
|
||
14
|
TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
OO
|
(1)
|
This Schedule 13D/A is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13D/A.
|
(2)
|
Includes (i) 447,957 shares held by VHCP and (ii) 81,943 shares held by VHCP Co. VHCPM is the sole general partner of VHCP and the sole manager of VHCP Co.
|
(3)
|
The shares included on rows 8, 10 and 11 do not include an aggregate of 783,022 shares held by VAIV, VP and VEFIV, 87,387 shares of which are issuable upon the exercise of options held by Hove for the sole benefit of VRM, which options are exercisable within 60 days of the date of this filing. The Venrock Healthcare Entities disclaim beneficial ownership over the shares held by the Venrock IV Entities.
|
(4)
|
This percentage is based upon 44,023,338 shares of the Issuer’s common stock outstanding as of August 3, 2015, as reported in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on August 7, 2015.
|
CUSIP No. 032420101
|
Page 12 of 16
|
Reporting Persons
|
|
Shares
Held
Directly
|
|
Sole
Voting
Power
|
|
Shared
Voting
Power (1)
|
|
Sole
Dispositive
Power
|
|
Shared
Dispositive
Power (1)
|
|
Beneficial
Ownership
|
|
Percentage
of Class
|
||||||||||||||
VAIV
|
|
566,247
|
|
|
0
|
|
|
783,022 (2)
|
|
|
0
|
|
|
783,022 (2)
|
|
|
783,022 (2)
|
|
|
1.8
|
% (3)
|
|||||||
VP
|
|
115,475
|
|
|
0
|
|
|
783,022 (2)
|
|
|
0
|
|
|
783,022 (2)
|
|
|
783,022 (2)
|
|
|
1.8
|
% (3)
|
|||||||
VEFIV
|
|
13,913
|
|
|
0
|
|
|
783,022 (2)
|
|
|
0
|
|
|
783,022 (2)
|
|
|
783,022 (2)
|
|
|
1.8
|
% (3)
|
|||||||
VRM
|
|
0
|
|
|
0
|
|
|
783,022 (2)
|
|
|
0
|
|
|
783,022 (2)
|
|
|
783,022 (2)
|
|
|
1.8
|
% (3)
|
|||||||
VMIV
|
|
0
|
|
|
0
|
|
|
783,022 (2)
|
|
|
0
|
|
|
783,022 (2)
|
|
|
783,022 (2)
|
|
|
1.8
|
% (3)
|
|||||||
VPM
|
|
0
|
|
|
0
|
|
|
783,022 (2)
|
|
|
0
|
|
|
783,022 (2)
|
|
|
783,022 (2)
|
|
|
1.8
|
% (3)
|
|||||||
VEFMIV
|
|
0
|
|
|
0
|
|
|
783,022 (2)
|
|
|
0
|
|
|
783,022 (2)
|
|
|
783,022 (2)
|
|
|
1.8
|
% (3)
|
|||||||
VHCP
|
|
447,957
|
|
|
0
|
|
|
529,900
|
|
|
0
|
|
|
529,900
|
|
|
529,900
|
|
|
1.2
|
% (4)
|
|||||||
VHCP Co.
|
|
81,943
|
|
|
0
|
|
|
529,900
|
|
|
0
|
|
|
529,900
|
|
|
529,900
|
|
|
1.2
|
% (4)
|
|||||||
VHCPM
|
|
0
|
|
|
0
|
|
|
529,900
|
|
|
0
|
|
|
529,900
|
|
|
529,900
|
|
|
1.2
|
% (4)
|
(1)
|
VMIV, VPM and VEFMIV serve as the sole general partner of VAIV, VP and VEFIV, respectively. VMIV, VRM, VPM and VEFMIV own no securities of the Issuer directly. VHCPM serves as the sole general partner of VHCP and the sole manager of VHCP Co.
|
(2)
|
Includes 87,387 shares underlying options held by Anders Hove (“Hove”) that are exercisable within 60 days of the date of this filing. Under an agreement between Hove and VRM, Hove is deemed to hold the shares at the direction, and for the sole benefit of, VRM.
|
(3)
|
This percentage is based upon (i) 44,023,338 shares of the Issuer’s common stock outstanding as of August 3, 2015, as reported in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on August 7, 2015 plus (ii) 87,387 shares of Common Stock issuable upon the exercise of options beneficially owned by the Reporting Person within 60 days of the date of this filing.
|
(4)
|
This percentage is based upon 44,023,338 shares of the Issuer’s common stock outstanding as of August 3, 2015, as reported in the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on August 7, 2015.
|
(c)
|
The distributions effected on November 3, 2015, as described in Item 4 hereof, were effected as follows:
|
Venrock Entity
|
|
Number of Shares Distributed to Partners/Members
|
||
VAIV
|
|
693,061
|
|
|
VP
|
|
141,337
|
|
|
VEF
|
|
17,028
|
|
|
VHCP
|
|
548,279
|
|
|
VHCP Co.
|
|
100,295
|
|
CUSIP No. 032420101
|
Page 13 of 16
|
VENROCK ASSOCIATES IV, L.P.
By its General Partner, Venrock Management IV, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp, Authorized Signer
|
||
VENROCK ENTREPRENEURS FUND IV, L.P.
By its General Partner, VEF Management IV, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp, Authorized Signer
|
||
VENROCK PARTNERS, L.P.
By its General Partner, Venrock Partners Management, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp, Authorized Signer
|
||
VENROCK HEALTHCARE CAPITAL PARTNERS, L.P.
By its General Partner, VHCP Management, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp, Authorized Signer
|
||
VHCP CO-INVESTMENT HOLDINGS, LLC
By its Manager, VHCP Management, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp, Authorized Signer
|
||
VENROCK MANAGEMENT IV, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp, Authorized Signer
|
CUSIP No. 032420101
|
Page 14 of 16
|
VENROCK PARTNERS MANAGEMENT, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp, Authorized Signer
|
||
VEF MANAGEMENT IV, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp, Authorized Signer
|
||
VHCP MANAGEMENT, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp, Authorized Signer
|
||
VR MANAGEMENT, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp, Authorized Signer
|
CUSIP No. 032420101
|
Page 15 of 16
|
VENROCK ASSOCIATES IV, L.P.
By its General Partner, Venrock Management IV, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp, Authorized Signer
|
||
VENROCK ENTREPRENEURS FUND IV, L.P.
By its General Partner, VEF Management IV, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp, Authorized Signer
|
||
VENROCK PARTNERS, L.P.
By its General Partner, Venrock Partners Management, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp, Authorized Signer
|
||
VENROCK HEALTHCARE CAPITAL PARTNERS, L.P.
By its General Partner, VHCP Management, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp, Authorized Signer
|
||
VHCP CO-INVESTMENT HOLDINGS, LLC
By its Manager, VHCP Management, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp, Authorized Signer
|
||
VENROCK MANAGEMENT IV, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp, Authorized Signer
|
||
CUSIP No. 032420101
|
Page 16 of 16
|
VENROCK PARTNERS MANAGEMENT, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp, Authorized Signer
|
||
VEF MANAGEMENT IV, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp, Authorized Signer
|
||
VHCP MANAGEMENT, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp, Authorized Signer
|
||
VR MANAGEMENT, LLC
|
||
By:
|
/s/ David L. Stepp
|
|
David L. Stepp, Authorized Signer
|